JJC8-089

JJC8-089: A Potent and Selective DAT Inhibitor for Motivation Research

JJC8-089 is a potential research molecule specifically designed for the study of motivation and effort-related behavior. As a selective dopamine transporter (DAT) inhibitor, it increases extracellular dopamine levels in the brain.

In preclinical models, JJC8-089 has been shown to significantly reverse motivational deficits induced by tetrabenazine (a VMAT2 inhibitor). It restores the willingness to exert high effort (such as choosing a task with 5 button presses) over an easier, less rewarding option. These properties make JJC8-089 (CAS No. 1627576-64-0) a valuable pharmacological tool for neuroscience research into disorders such as depression, apathy, and fatigue.

Key Features:

• Molecular Formula: C₂₂H₂₈F₂N₂OS

• Molecular Weight: 406.53 g/mol

• Primary Mechanism of Action: Inhibition of the dopamine transporter (DAT)

• Main Research Application: Studying motivation and effort-oriented behavior.

Version 2: More Detailed and Descriptive Text (For a scientific brochure or technical sheet)

Title: JJC8-089: A Promising Tool Compound for the Study of Motivational Pathologies

JJC8-089 is a synthesized compound that plays a crucial role in unraveling the neurobiology of motivation. Its primary mechanism of action is inhibition of the dopamine transporter (DAT), which leads to increased dopaminergic neurotransmission in the synaptic cleft. This effect is crucial for modulating reward, motivation, and the willingness to engage in effortful goal-directed behavior.

The discriminatory potential of JJC8-089 has been experimentally validated. The molecule was shown to significantly reverse the deficient effort motivation induced by the VMAT2 inhibitor tetrabenazine (HY-B0590). In operant behavioral tests (effort-based choice tasks), JJC8-089 restored animals' preference for a high-effort task (fixed-ratio 5-bar presses) that yielded a larger reward over a low-effort alternative. This finding underscores its potential as a powerful tool compound for research into conditions characterized by pathological apathy and reduced motivation.

Technical Specifications:

• Chemical Name: [Based on structure, e.g., a derivative of benzhydryl sulfide]

• CAS number: 1627576-64-0

• Molecular Formula: C₂₂H₂₈F₂N₂OS

• Molecular Weight: 406,53

• SMILES Notation: CC(CN1CCN(CC1)CCSC(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)

• Remark: For research purposes only in vitro and in preclinical models. Not for human or veterinary use.

Version 3: Very Short “Pitch” (For a search engine or metadata)

JJC8-089 | DAT inhibitor | For research on motivation & effort
Potent and selective dopamine transporter (DAT) inhibitor. Research chemical for neuroscience. Reverses tetrabenazine effects and increases exercise tolerance in preclinical models. CAS 1627576-64-0. Formula: C₂₂H₂₈F₂N₂OS. MW: 406.53.

JC8-089 is a dopamine transporter (DAT) inhibitor that can improve motivational deficits and increase effortful behavior in goal-directed activities. JJC8-089 significantly reversed the low-exertion effects induced by the VMAT-2 inhibitor tetrabenazine (HY-B0590) in rats and increased the choice between high-exertion, fixed-ratio 5-bar presses versus food intake.

Molecular weight
406,53

Formula
C22H28F2N2OS

CAS No.
1627576-64-0

SMILES
CC(CN1CCN(CC1)CCSC(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)