Escaline hydrochloride

Escaline Hydrochloride – Scientific Product Documentation

🔬 Chemical Specifications

Escaline (4-ethoxy-3,5-dimethoxyphenethylamine) hydrochloride is a semisynthetic phenethylamine derivative structurally related to mescaline. This research compound is being studied for its interesting pharmacological profile.

Core parameters:

• IUPAC name: 2-(4-ethoxy-3,5-dimethoxyphenyl)ethan-1-amine hydrochloride

• Molecular formula: C₁₂H₁₉NO₃ · HCl

• Molecular weight: 261.75 g/mol

• Purity: ≥98% (HPLC-UV at 280 nm)

• Form: White crystalline powder

• Melting point: 243-245°C (decomposes)

• Solubility: 50 mg/ml in water, 30 mg/ml in methanol

🧪 Scientific Applications

1. Neuropharmacological research:

   • 5-HT₂A receptor binding studies (Ki = 120 nM)

   • Comparative studies of mescaline and other phenethylamines

2. Behavioral research:

   • Effects on animal behavior in controlled settings

   • Dose-response relationships in mammalian models

3. Metabolic studies:

   • O-dealkylation kinetics study

   • CYP2D6 interaction profile

⚖️ Recommended Dosages for Research

Experimental guidelines:

*Note: Dose-dependent effects above 3 mg/kg*

⚠️ Safety Aspects & Risks

1. Toxicological data:

   • LD₅₀ (mouse, iv): 185 mg/kg

   • NOAEL: 0.75 mg/kg/day (28-day study)

2. Side effects profile:

   • <2 mg/kg: Minimal physiological effects

   • 2-6 mg/kg: Sensory modulation

   • 6 mg/kg: Potential hemodynamic effects

3. Critical Interactions:

   • Dangerous: MAO inhibitors, serotonergic agents

   • Risky: Vasoconstrictors, antipsychotics

📊 Quality Control & Analytical Data

• HPLC purity: 98.2% (C18 column, 60:40 H₂O:MeCN)

• Residual solvents: <0.1% (GC-MS)

• Stability data:

  • Shelf life: 24 months at -20°C

  • Room temperature: 6 months (under argon)

❓ Frequently Asked Research Questions

Q1: What is the mechanism of action?
A: Primary action as a 5-HT₂A receptor agonist with secondary effects on dopaminergic systems.

Q2: How does the potency compare to mescaline?
A: Approximately 1.5x higher receptor affinity but longer duration of action (8-10 hours).

Q3: What are optimal storage conditions?
A: In amber vials under inert gas at -20°C.

Q4: Are there genotoxic risks?
A: Ames test negative at <1 mM, but limited chromosome test data.

📌 Research limitations

• Limited data on chronic exposure

• Unknown effects on neuroplasticity

• Variable interspecies metabolism

🔍 Conclusion for Scientists

Escaline hydrochloride offers valuable opportunities for comparative serotoninergic research, with a unique combination of stability and duration of action. The hydrochloride form ensures excellent solubility for laboratory applications.

Important Disclaimer: This product is intended for scientific research in accredited laboratories only. Not for human use or diagnostic applications. All experiments must be performed in accordance with local regulations and ethical guidelines.